首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   9956篇
  免费   348篇
  国内免费   69篇
耳鼻咽喉   60篇
儿科学   184篇
妇产科学   119篇
基础医学   1217篇
口腔科学   107篇
临床医学   1984篇
内科学   596篇
皮肤病学   141篇
神经病学   789篇
特种医学   146篇
外科学   551篇
综合类   1927篇
预防医学   1242篇
眼科学   47篇
药学   836篇
  14篇
中国医学   254篇
肿瘤学   159篇
  2024年   10篇
  2023年   150篇
  2022年   238篇
  2021年   346篇
  2020年   333篇
  2019年   361篇
  2018年   311篇
  2017年   302篇
  2016年   294篇
  2015年   307篇
  2014年   841篇
  2013年   824篇
  2012年   872篇
  2011年   841篇
  2010年   698篇
  2009年   540篇
  2008年   513篇
  2007年   459篇
  2006年   351篇
  2005年   251篇
  2004年   202篇
  2003年   174篇
  2002年   129篇
  2001年   118篇
  2000年   94篇
  1999年   71篇
  1998年   45篇
  1997年   43篇
  1996年   24篇
  1995年   31篇
  1994年   32篇
  1993年   13篇
  1992年   11篇
  1991年   11篇
  1990年   15篇
  1989年   8篇
  1988年   14篇
  1987年   13篇
  1985年   54篇
  1984年   74篇
  1983年   46篇
  1982年   62篇
  1981年   59篇
  1980年   39篇
  1979年   39篇
  1978年   24篇
  1977年   26篇
  1976年   17篇
  1975年   9篇
  1974年   8篇
排序方式: 共有10000条查询结果,搜索用时 127 毫秒
51.
Background and objectivesFew studies have investigated the role psychological inflexibility (PI) could have in the context of chronic renal failure. The primary objective of this study was to analyse the psychometric features, the reliability and the validity of the Spanish version of the Acceptance and Action Questionnaire-II (AAQ-II) adapted to the context of patients undergoing haemodialysis (HD). The secondary objective was to assess the relationship between PI and parameters related to the adherence to treatment and quality of life in these types of patients.Materials and methodsProspective cross-sectional study with patients on haemodialysis (n = 186).ResultsThe fat tissue index (15.56 ± 5.72 vs. 18.99 ± 8.91, P = .033), phosphorus levels (3.92 ± 1.24 vs. 4.66 ± 1.38; P = .001) and interdialytic weight gain (1.56 ± 0.69 vs. 1.89 ± 0.93, P = .016) were higher in patients with a higher PI score. Phosphorus levels (P = .013) significantly explained the variability of PI levels. PI was also shown as a significant predictor (P = .026) of the variability of phosphorus levels.ConclusionsThe adaptation of the AAQ-II questionnaire to the HD context led to a valid and reliable measurement of PI in these types of patients and our results also seem to support the relationship between PI and health and quality of life parameters in patients with chronic conditions.  相似文献   
52.
IntroductionThe aim of this study was to know, through a national survey, the methods and techniques used for the diagnosis of Helicobacter pylori (Hp) in the different Clinical Microbiology Services/Laboratories in Spain, as well as antibiotic resistance data.MethodsThe survey requested information about the diagnostic methods performed for Hp detection in Clinical Microbiology laboratories, including serology, stool antigen, culture from gastric biopsies, and PCR. In addition, the performance of antibiotic susceptibility was collected. Data on the number of samples processed in 2016, positivity of each technique and resistance data were requested. The survey was sent by email (October-December 2017) to the heads of 198 Clinical Microbiology Laboratories in Spain.ResultsOverall, 51 centers from 29 regions answered the survey and 48/51 provided Hp microbiological diagnostic testing. Concerning the microbiological methods used to diagnose Hp infection, the culture of gastric biopsies was the most frequent (37/48), followed by stool antigen detection (35/48), serology (19/48) and biopsy PCR (5/48). Regarding antibiotic resistance, high resistance rates were observed, especially in metronidazole and clarithromycin (over 33%).ConclusionCulture of gastric biopsies was the most frequent method for detection of Hp, but the immunochromatographic stool antigen test was the one with which the largest number of samples were analyzed. Nowadays, in Spain, it concerns the problem of increased antibiotic resistance to ‘first-line’ antibiotics.  相似文献   
53.
目的分析心理护理对于帕金森患者焦虑状态的影响。方法选取2018年1月-2019年8月佛山市禅城区中心医院收治的282例帕金森患者,将其随机分为对照组和观察组,每组各141例。对照组患者行常规护理措施,观察组患者在对照组基础上加强心理护理。比较两组患者护理后的蒙特利尔认知评估量表(MoCA)评分、生存质量评分以及焦虑自评量表(SAS)评分。结果观察组患者护理后的MoCA评分、生存质量评分高于对照组;观察组实施护理后的SAS评分低于对照组,差异均有统计学意义(P<0.05)。结论在帕金森患者护理中加以心理护理能够改善患者焦虑状态,护理效果良好,能够促进患者早日康复。  相似文献   
54.
IntroductionThis study was designed to investigate yoga teachers' and yoga therapists’ perceptions of the ways yoga is applied to treat symptoms of psychological distress, and identify the defining features, main components, and mechanisms of change in therapeutic practice.MethodsA qualitative design was employed. Six yoga teachers who had specific training and experience in teaching therapeutic yoga or practicing ‘yoga therapy’ took part in one-to-one interviews during which they gave accounts of their experiences of helping people cope with psychological distress through yoga. Participants' interviews were transcribed verbatim and were analysed using an integrative inductive-deductive thematic analysis.ResultsFour key themes were identified in relation to the benefits of therapeutic yoga: Awareness, Choice, Relationships, and Tailoring.ConclusionsThe findings support previous research which suggests that individualised yoga therapy is a promising intervention, and may help to form a theoretical rationale for the future treatment of psychological distress with yoga.  相似文献   
55.
目的 探讨赋能心理护理对ICU患者家属心理压力及应对方式的影响。方法 选取2017年1-12月我院收治的120例ICU患者的主要照顾家属为研究对象,采用随机数字表法将其分为观察组及对照组,每组各60例。对照组行常规健康宣教,观察组在对照组基础上行赋能心理干预,比较2组心理压力、自我效能及应对方式。结果 干预后,观察组自我效能评分、积极应对方式评分均明显高于对照组(t=8.477,P<0.001;t=10.845,P<0.001),而消极应对方式评分明显低于对照组(t=8.935,P<0.001)。观察组紧张感、失控感及心理压力总评分均明显低于对照组(P<0.001)。结论 赋能心理干预能有效提高ICU重症患者家属自我效能,使家属能积极面对患者病情,减轻患者家属心理负担。  相似文献   
56.
Metabolic acidosis, which can be affected by dietary acid-base load, seems to be associated with psychological disorders through different pathways. Given limited evidence on dietary acid-base load, we aimed to examine the association of dietary acid-base load with psychological disorders in Iranian women. This cross-sectional study was performed on 447 female subjects (20–50 years old). Dietary intake was assessed using a valid food frequency questionnaire for Iran. Dietary acid-base load was calculated through different indices including potential renal acid load (PRAL), net endogenous acid production (NEAP), and dietary acid load (DAL). To assess psychological disorders, an Iranian validated version of depression, anxiety, and stress scale (DASS-21) was used. The mean value of PRAL, NEAP, and DAL were -8.87mEq/da, 37.94mEq/day, and 30.77mEq/day, respectively. Considering a wide range of confounding variables, compared with the first tertile, a significant positive association was observed between dietary acid-base load and depression (ORPRAL: 3.63; 95 %CI:1.97, 6.71; Ptrend = 0.0001) (ORNEAP:3.42; 95 %CI: 1.87, 6.23; Ptrend = 0.0001) (ORDAL: 3.02; 95 %CI: 1.64, 5.58; Ptrend = 0.0001). Women in the high dietary acid-base load category had higher anxiety (ORPRAL: 3.31; 95 %CI: 1.81, 6.06; Ptrend = 0.0001) (ORNEAP:3.47; 95 %CI: 1.90, 6.33; Ptrend = 0.0001) (ORDAL: 3.25; 95 %CI: 1.76, 5.98; Ptrend = 0.0001). Moreover, there was a strong positive relationship between dietary acid-base load and psychologicaldistress (ORPRAL: 3.79; 95 %CI: 2.09, 6.90; Ptrend = 0.0001) (ORNEAP: 3.67; 95 %CI: 2.04, 6.58; Ptrend = 0.0001) (ORDAL: 3.00; 95 %CI: 1.66, 5.43; Ptrend = 0.0001). Women with higher dietary acid-base load score had greater odds for depression, anxiety, and psychological distress compared to lower ones.  相似文献   
57.
BackgroundIn the last decade, many novel minimally invasive surgical techniques within benign prostatic hyperplasia (BPH) surgery were developed to reduce postoperative complications that often discourage patients from pursuing BPH surgery.AimTo assess perspective of future and past international BPH surgery patients regarding their postoperative complications, namely erectile and ejaculatory function.MethodsA survey was distributed randomly to 2 groups of BPH patients: one with 149 patients having undergone surgery in the last 2 years (group A), and the other cohort of 151 men seriously considering BPH surgery in the next year (group B). This survey consisted of 20 questions that assessed patients' motivating factors for undergoing elective BPH surgery and their perspectives regarding the potential postoperative complications attributed to BPH surgery.OutcomesThe perspective of future and past international BPH surgical patients towards the preservation of their erectile and ejaculatory functions was assessed with the help of a survey.ResultsResults indicated that in general BPH surgery patients considered the maintenance of erectile (95%, n = 284) and ejaculatory function (92%, n = 276) to be important preoperative considerations, regardless of their age. Patients aged 50–59 years were most concerned with the permanent impact on sexual function and patients aged >60 years were most concerned with urinary incontinence. In patients aged >70 years, 66% (n = 43) and 62% (n = 40) of the respondents indicated that maintaining erectile and ejaculatory function was important, respectively.Clinical ImplicationsPatient-centered care needs to be implemented in order to address the importance that past and future BPH surgery patients hold toward the maintenance of their postoperative sexual function.Strengths & LimitationsIn the group of patients having previously undergone BPH surgery, the possibility of recall bias should be taken into account when interpreting the study's findings. However, maintaining sexual function was also important for the group of patients seriously considering surgery in the next year suggesting that these considerations are not solely due to recall bias. Additionally, the results were limited by the small sample size of participants in groups A (n = 149) and B (n = 151).ConclusionIt was found that past and future BPH surgery patients attribute a significant importance toward the maintenance of their sexual function. Although novel approaches with better sexual outcomes such as Rezum and UroLift for prostates <80 mL, and Aquablation for any size prostate are available, more research is needed to investigate their long-term effects on sexual function before they can be recommended to patients.Bouhadana D, Nguyen D-D, Zorn KC, et al. Patient Perspectives on Benign Prostatic Hyperplasia Surgery: A Focus on Sexual Health. J Sex Med 2020;17:2108–2112.  相似文献   
58.

Background

Numerous studies have reported people with disabilities are more likely to be obese and engaged in unhealthy lifestyles. Few studies explored the mechanism of health-related lifestyles and obesity among people with disabilities.

Objective

We aimed to investigate health-related lifestyles and obesity in relation to disability among Australian adults. We further aimed to explore the potential mediating effect of psychological distress for disability in relation to health related lifestyles and obesity.

Methods

Using the National Health Survey conducted in 2015 in Australia, we considered non-institutionalised adult participants (aged 18 + years old) as our study population (n = 11,598). Study outcomes included currently smoking, smoking daily, alcohol consumption, physical exercises, and obesity. We considered high psychological distress (Kessler 10 scores ≥ 22) a potential mediator for the disability-lifestyles and disability-obesity associations. Sample weights were calculated allowing for complex survey design. Adjusted Odds Ratios and 95% Confidence Intervals were evaluated using weighted Logistic regression models.

Results

Compared to their disability-free counterparts, people with disabilities were more likely to be current smokers (aOR: 1.26, 95%CI: 1.08–1.47) and have obesity problems (1.44, 1.27–1.64), and were less likely to do physical exercises (0.67, 0.58–0.77), after controlling for socio-environmental factors. In the presence of high psychological distress, the disability-smoking association was no longer significant, and associations of disability-exercise (0.72, 0.62–0.84) and disability-obesity (1.38, 1.22–1.57) were influenced but remained significant.

Conclusion

High psychological distress demonstrated important mediating effects. Tailored mental health care for people with disabilities might have the utility to reduce unhealthy behaviors.  相似文献   
59.
60.

Purpose

Using planning target volume (PTV) to account for setup uncertainties in stereotactic body radiation therapy (SBRT) of lung cancer has been questioned because a significant portion of the PTV contains low-density lung tissue. The purpose of this study is to (1) investigate the feasibility of using robust optimization to account for setup uncertainties in volumetric modulated arc therapy plan for lung SBRT and (2) evaluate the potential normal tissue–sparing benefit of a robust optimized plan compared with a conventional PTV-based optimized plan.

Methods and materials

The study was conducted with both phantom and patient cases. For each patient or phantom, 2 SBRT lung volumetric modulated arc therapy plans were generated, including an optimized plan based on the PTV (PTV-based plan) with a 5-mm internal target volume (ITV)-to-PTV margin and a second plan based on robust optimization of ITV (ITV-based plan) with ±5-mm setup uncertainties. The target coverage was evaluated on ITV D99 in 15 scenarios that simulated a 5-mm setup error. Dose-volume information on normal lung tissue, intermediate-to-high dose spillage, and integral dose was evaluated.

Results

Compared with PTV-based plans, ITV-based robust optimized plans resulted in lower normal lung tissue dose, lower intermediate-to-high dose spillage to the body, and lower integral dose, while preserving the dose coverage under setup error scenarios for both phantom and patient cases.

Conclusions

Using ITV-based robust optimization, we have shown that accounting for setup uncertainty in SBRT planning is feasible. Further clinical studies are warranted to confirm the clinical effectiveness of this novel approach.  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号